Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 6 de 6
Filtrar
1.
Arq. bras. cardiol ; 119(4 supl.1): 121-121, Oct, 2022.
Artigo em Inglês | CONASS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1397297

RESUMO

INTRODUCTION: Out-of-Office Measurement of Blood Pressure (BP) is recommended in addition to office BP for the diagnosis and follow-up of hypertensive patients. Ambulatory Blood Pressure Monitoring (ABPM); Home Blood Pressure Monitoring (HBPM); and Self-Monitoring of BP (SMBP) are the currently available options and their indication may vary according to the context. The aim of the present study was to assess how Out-of-Office Measurement of BP takes place in clinical practice and its impact on BP control in a public tertiary outpatient clinic. METHODS: We evaluated 225 consecutive patients seen at a high-complexity public outpatient facility (mean age: 66.7 ± 11.9 years; female: 62.7%). All patients were routinely requested to perform SMBP according to a prespecified institutional protocol. ABPM and HBPM were indicated for selected cases at the discretion of the attending physician. Patient Adherence to Out-of-Office Measurement of BP was labeled into 5 possible categories: a) No Measurement; b) ABPM; c) HBPM; d) Adequate SMBP e) Inadequate SMBP. Patient Adherence was also stratified according to sex, age, number of antihypertensive drugs, schooling, length of follow-up at the facility, comorbidities and availability of BP monitor at home. Rates of BP control were related with Patient Adherence, as well as with the aforementioned variables. RESULTS: 87.5% of the study population reported having a BP monitor at home. However, adding up the 5 possible categories, adequate Out-of-Office Measurement of BP was available in only 46.7% of the sample (40.9% of the patients did not bring any measurement; 13.8% underwent ABPM; 32.9% adequate SMBP; 12.4% inadequate SMBP; 0% HBPM). Availability of a BP monitor at home (p<0.001) and the number of antihypertensive drugs in use (p=0.019) were strongly associated with adherence to SMBP. Prevalence of smoking was 2 folds higher (7.5% vs 3.4%) in those who returned without SMBP. Rate of BP control based on office BP was 42.6% (79.5% of the sample was under ≥3 classes of antihypertensive drugs). Out-of-office BP measurements were not associated with higher rates of BP control (p=0.377), but allowed to identify a White Coat Effect (WCE) in 1 out of 3 patients with uncontrolled BP according to office BP (WCE prevalence: 29 % among uncontrolled patients vs 3.9% among controlled ones. CONCLUSIONS: Outof-Office Measurement of BP is still an unmet need in the treatment of hypertension.


Assuntos
Monitorização Ambulatorial da Pressão Arterial , Hipertensão , Anti-Hipertensivos
2.
Einstein (Sao Paulo) ; 18: eAO5448, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-32965298

RESUMO

OBJECTIVE: To characterize the processes of brain death diagnosis and organ donation in a reference trauma center. METHODS: Observational and cross-sectional study with patients notified with brain death at a reference trauma center. Data were obtained through the collection of medical records and brain death declaration forms. RESULTS: One hundred fity-nine patients were notified with brain death, mostly male (82.6%), young adults (97.61%) and victims of brain traumatic injury (93.7%). Median of the total time interval for the diagnosis of brain death was 20.75 hours, with no difference between organ donors and non-donors. We had excessive time intervals on brain death declaration, but without statistical effect on organ donation numbers. CONCLUSION: We had low efficacy in brain death declaration based on longer time intervals, with no impact on organ donation.


Assuntos
Morte Encefálica , Transplante de Órgãos , Obtenção de Tecidos e Órgãos , Estudos Transversais , Humanos , Masculino , Estudos Retrospectivos , Doadores de Tecidos , Centros de Traumatologia , Adulto Jovem
3.
Einstein (Säo Paulo) ; 18: eAO5448, 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1133724

RESUMO

ABSTRACT Objective To characterize the processes of brain death diagnosis and organ donation in a reference trauma center. Methods Observational and cross-sectional study with patients notified with brain death at a reference trauma center. Data were obtained through the collection of medical records and brain death declaration forms. Results One hundred fity-nine patients were notified with brain death, mostly male (82.6%), young adults (97.61%) and victims of brain traumatic injury (93.7%). Median of the total time interval for the diagnosis of brain death was 20.75 hours, with no difference between organ donors and non-donors. We had excessive time intervals on brain death declaration, but without statistical effect on organ donation numbers. Conclusion We had low efficacy in brain death declaration based on longer time intervals, with no impact on organ donation.


RESUMO Objetivo Caracterizar os processos de diagnóstico de morte encefálica e doação de órgãos em um centro de referência de trauma. Métodos Estudo observacional e transversal com pacientes notificados com morte encefálica em um centro de referência de trauma. Os dados foram obtidos por meio da coleta de prontuários e formulários de declaração de morte encefálica. Resultados Foram notificados com morte encefálica 159 pacientes, com prevalência do sexo masculino (82,6%), adultos jovens (97,61%) e vítimas de traumatismo craniencefálico (93,7%). A mediana do intervalo total de tempo para o diagnóstico de morte encefálica foi de 20,75 horas, sem diferença entre doadores de órgãos e não doadores. Tivemos intervalos de tempo excessivos na declaração de morte encefálica, mas sem efeito estatístico no número de doações de órgãos. Conclusão Foi baixa a eficácia na declaração de morte encefálica com base em intervalos de tempo mais longos, sem impacto na doação de órgãos.


Assuntos
Humanos , Masculino , Adulto Jovem , Obtenção de Tecidos e Órgãos , Morte Encefálica , Transplante de Órgãos , Doadores de Tecidos , Centros de Traumatologia , Estudos Transversais , Estudos Retrospectivos
4.
Belém; s.n; 2018. 48 p.
Tese em Português | Coleciona SUS | ID: biblio-1343729

RESUMO

A constatação clinica de morte encefálica (ME) é essencial na obtenção de órgãos para transplante, sendo este uma medida terapêutica e extrema relevância, pois é a única alternativa para pacientes portadores de determinadas doenças terminais. O objetivo do trabalho foi caracterizar os processos de diagnostico de ME e de doação de órgãos no hospital Metropolitano de Urgência e Emergência. O estudo desenvolvido foi observacional, transversal e descritivo. Os pesquisadores utilizaram prontuários, termos de declaração de ME e protocolos de doação de órgãos de 159 pacientes diagnosticados com ME entre os anos de 2014 e 2017. Foram coletados dados epidemiológicos e informações concernentes aos processos de diagnóstico de ME, de manutenção do potencial doador (PD) e de doação de órgãos. A maioria dos pacientes pertencia ao gênero masculino (87,5%). encontrava-se na faixa etária de 21 a 40 anos (52,8%) e era proveniente do interior do Estado (85%). O acidente motociclístico foi o principal motivo de admissão (38,36%). Em acréscimo, identificou-se demora considerável no processo de diagnostico de ME, com poucos pacientes (28,3%) evoluindo sem complicações clínicas durante a internação. Evidenciou-se também que as principais causas de recusa para doação foram: desejo de corpo integro (32,04%) e motivos familiares (25,24%). Conclui-se, dessa forma, que o processo de doação de órgãos apresenta dificuldades no que se refere ao diagnostico e à manutenção do PD e à aceitação familiar, o que pode ser sanado com melhor educação tanto dos profissionais quanto dos cidadãos (AU)


The clinical establishment of brain death (BD) is essential for obtainment of organs for transplantation, which is a therapeutic measure and extremely relevant, as it is the only alternative for patients with certain terminal illnesses. The objective of this work was to characterize the processes of diagnosis of BD and organ donation in the Metropolitan Hospital of Urgency and Emergency. The study developed was observational, cross-sectional and descriptive. The researchers used medical records, BD declaration terms and organ donation protocols from 159 patients diagnosed with BD between 2014 and 2017. Epidemiological data and information concerning the processes of BD diagnosis and maintenance of potential donors were collected ( PD) and organ donation. Most patients were male (87.5%). he was aged between 21 and 40 years (52.8%) and came from the interior of the state (85%). Motorcycle accidents were the main reason for admission (38.36%). In addition, a considerable delay in the BD diagnosis process was identified, with few patients (28.3%) evolving without clinical complications during hospitalization. It was also evident that the main causes of refusal to donate were: desire for a whole body (32.04%) and family reasons (25.24%). Thus, it is concluded that the organ donation process presents difficulties with regard to the diagnosis and maintenance of PD and family acceptance, which can be remedied with better education of both professionals and citizens


Assuntos
Humanos , Masculino , Feminino , Morte Encefálica/diagnóstico , Morte Encefálica/legislação & jurisprudência , Perfil de Saúde , Obtenção de Tecidos e Órgãos/legislação & jurisprudência
5.
Acta Cir Bras ; 31(9): 597-601, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27737344

RESUMO

PURPOSE:: To assess antioxidant effects of açaí seed extract on anorexia-cachexia induced by Walker-256 tumor. METHODS:: A population of 20 lab rats were distributed into four groups (n=5): Control Group (CG), which only received tumor inoculation. Experimental Group-100 (EG-100), with animals submitted to tumor inoculation and treated with seed extract in a 100 mg / ml concentration through gavage. Experimental Group-200 (EG-200), with animals submitted to tumor inoculation and treated with seed extract in a 200 mg / ml concentration. Placebo Group (GP), which received tumor inoculation and ethanol-water solution. We analyzed proteolysis, lipid peroxidation, tumor diameter and weight. RESULTS:: Lipid peroxidation was representative only in the cerebral cortex, where there was more oxidative stress in rats treated with the extract (p = 0.0276). For proteolysis, there was less muscle damage in untreated rats (p = 0.0312). Only tumor diameter in treated rats was significantly lower (p = 0.0200) compared to untreated ones. CONCLUSIONS:: The açaí seed extract showed no beneficial effect on the general framework of the cachectic syndrome in lab rats. However, some anticarcinogenic effects were observed in the tumor diameter and weight.


Assuntos
Anorexia/tratamento farmacológico , Antioxidantes/farmacologia , Caquexia/tratamento farmacológico , Euterpe/química , Extratos Vegetais/uso terapêutico , Sementes/química , Análise de Variância , Animais , Anorexia/etiologia , Antioxidantes/análise , Caquexia/etiologia , Carcinoma 256 de Walker/complicações , Córtex Cerebral/enzimologia , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Neoplasias Experimentais/complicações , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/farmacologia , Ratos Wistar , Síndrome , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
6.
Acta cir. bras ; 31(9): 597-601, Sept. 2016. tab, graf
Artigo em Inglês | LILACS | ID: lil-795995

RESUMO

ABSTRACT PURPOSE: To assess antioxidant effects of açaí seed extract on anorexia-cachexia induced by Walker-256 tumor. METHODS: A population of 20 lab rats were distributed into four groups (n=5): Control Group (CG), which only received tumor inoculation. Experimental Group-100 (EG-100), with animals submitted to tumor inoculation and treated with seed extract in a 100 mg / ml concentration through gavage. Experimental Group-200 (EG-200), with animals submitted to tumor inoculation and treated with seed extract in a 200 mg / ml concentration. Placebo Group (GP), which received tumor inoculation and ethanol-water solution. We analyzed proteolysis, lipid peroxidation, tumor diameter and weight. RESULTS: Lipid peroxidation was representative only in the cerebral cortex, where there was more oxidative stress in rats treated with the extract (p = 0.0276). For proteolysis, there was less muscle damage in untreated rats (p = 0.0312). Only tumor diameter in treated rats was significantly lower (p = 0.0200) compared to untreated ones. CONCLUSIONS: The açaí seed extract showed no beneficial effect on the general framework of the cachectic syndrome in lab rats. However, some anticarcinogenic effects were observed in the tumor diameter and weight.


Assuntos
Animais , Masculino , Sementes/química , Caquexia/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Anorexia/tratamento farmacológico , Euterpe/química , Antioxidantes/farmacologia , Síndrome , Caquexia/etiologia , Extratos Vegetais/farmacologia , Carcinoma 256 de Walker/complicações , Peroxidação de Lipídeos/efeitos dos fármacos , Anorexia/etiologia , Córtex Cerebral/enzimologia , Análise de Variância , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Ratos Wistar , Estresse Oxidativo/efeitos dos fármacos , Neoplasias Experimentais/complicações , Antioxidantes/análise
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...